"Airbrush! What have you done to my father!" Everything Everything is a band I don't closely follow. I wouldn't even say I'm that huge of a fan of theirs, but their videos have haunted my dreams for the past two or three years. I saw this video debut last month and thought to myself, "Self, when's the last time you've had a collage-oriented nightmare." So yeah, in my eyes, they win.
Honorable Mention: Slaughterhouse "Microphone", Janelle Monae "Tightrope", Liberty University "Bed Intruder Carol", Cloud Nothings "Hey Cool Kid"
[Keep in mind that some of The Brog's selections may not necessarily been made in 2010. Its just the year I enjoyed them in and if you don't like it ... tough.]